Çalışmayla ilgili bilgi veren Colombia Üniversitesi Epidemioloji Bölümü öğretim üyesi Prof. Dr. Ezra Susser, araştırmayla, hamileliğin başından itibaren folik asit kullanımının, bebeklerde otizm riskini %40 azalttığının saptandığını belirtti. Araştırma, Norveç’te, anneleri, gebelik döneminde folik asit tüketen, 2002-2008 arasında doğan 85 bin çocuk üzerinde yürütüldü. 2011’de bu çocuklardaki otizm riskinin, hamilelik döneminde folik asit kullanmayan annelerin çocuklarına oranla %40 daha az olduğu saptandı.
Araştırmaya imza atanlardan Norveç Halk Sağlığı Enstitüsü’nden profesör Pal Suren, gebelikten 4 hafta önce ve gebelikle beraber 8 hafta boyunca folik asit kullanılmasının bebeklerde otizm riskini azalttığını, ancak folik asidin, Asperger sendromu gibi otizmin alt gruplarında herhangi bir önleyiciliğinin olmadığını belirtti.
Organizmalarda oluşan hasarı tamir edebilen ve DNA sentezi için vazgeçilmez olan folik asit, yeşil yapraklı sebzelerde, bezelyede, pirinçte,havuçta ve yumurtada bulunuyor. ABD’de, Kanada ve Şili’de, buğday unlarının içine dahil edilen folik asidin tüketimi kolaylaştırılıyor.
Importance Prenatal folic acid supplements reduce the risk of neural tube defects in children, but it has not been determined whether they protect against other neurodevelopmental disorders.
Objective: To examine the association between maternal use of prenatal folic acid supplements and subsequent risk of autism spectrum disorders (ASDs) (autistic disorder, Asperger syndrome, pervasive developmental disorder–not otherwise specified [PDD-NOS]) in children.
Design, Setting, and Patients The study sample of 85 176 children was derived from the population-based, prospective Norwegian Mother and Child Cohort Study (MoBa). The children were born in 2002-2008; by the end of follow-up on March 31, 2012, the age range was 3.3 through 10.2 years (mean, 6.4 years). The exposure of primary interest was use of folic acid from 4 weeks before to 8 weeks after the start of pregnancy, defined as the first day of the last menstrual period before conception.
Relative risks of ASDs were estimated by odds ratios (ORs) with 95% CIs in a logistic regression analysis. Analyses were adjusted for maternal education level, year of birth, and parity.
Main Outcome Measure Specialist-confirmed diagnosis of ASDs.
Results: At the end of follow-up, 270 children in the study sample had been diagnosed with ASDs: 114 with autistic disorder, 56 with Asperger syndrome, and 100 with PDD-NOS. In children whose mothers took folic acid, 0.10% (64/61 042) had autistic disorder, compared with 0.21% (50/24 134) in those unexposed to folic acid.
The adjusted OR for autistic disorder in children of folic acid users was 0.61 (95% CI, 0.41-0.90). No association was found with Asperger syndrome or PDD-NOS, but power was limited. Similar analyses for prenatal fish oil supplements showed no such association with autistic disorder, even though fish oil use was associated with the same maternal characteristics as folic acid use.
Conclusions and Relevance Use of prenatal folic acid supplements around the time of conception was associated with a lower risk of autistic disorder in the MoBa cohort. Although these findings cannot establish causality, they do support prenatal folic acid supplementation.